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KMID : 0363620190400040061
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Journal of Korean Oriental Medicine
2019 Volume.40 No. 4 p.61 ~ p.71
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Effects of Yuhyangjeongtong-san on Fracture Healing in Rats
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Kim Ki-Tae
Jo Na-Young
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Abstract
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Objectives: The purpose of this study is to determine the effect of Yuhyangjeongtong-san on the recovery of tibial fractures in rats.
Methods: In this study, osteocalcin and Calcitonin, CTX-2, TGF-β and BMP-2, which are used as indicators of bone formation, were analyzed after hematologic fractures using experimental rats. In addition, the fracture union process was confirmed using X-rays.
Results: Osteocalcin, Calcitonin and BMP-2 showed a significant increase compared with the control at 4 weeks. CTX-2 and TGF-β showed a significant increase compared with the control at 3 weeks. On X-ray, YJS treated group, as the experiment progressed, the boundary line became blurred, the bone outline was clearly visible, and the fracture recover was progressing.
Conclusion: The findings suggest that YJS can play a significant role in the repair of fractures. Therefore YJS is likely to be used to treat fractures.
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KEYWORD
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Yuhyangjeongtong-san, Fracture, Rat, Tibia, Korean medicine
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